Will Yoga Meditation make me lose interest in worldly activities?

Live in the world, yet above it!

May be! That all depends on how interested you are in whatever it is that you call worldly activities. Some activities might drop away. Rest assured, meditation does not mean you will sit around doing nothing. Nature does not like a vacuum; something else, something more meaningful and joyous will fill that space.

Meditation will help you prioritize your activities. Other activities may gain priority when you understand through meditation what you want to do with your life.